In there, it is actually promoting, that gains will be greater if you are on Testosterone treatment. I left a link in my “Fraud thread” for you and babbis. Nice evolution of this thread kristian69. I have a question: What about pills that makes your body produce more testosteron on its own, Is it possible that this could have any effect on PE? There has been a few threads about the effects that testosterone migth have on PE, Conclusions seems to be that it would not have any effect on PE after puberty.
Inhibition of wound contraction by papaverine: in vitro analysis with a submucosal tissue model.Įffect of trapidil and papaverine on thrombocyte aggregation and phosphodiesterase activity Papaverine hepatotoxicity is rarely a clinical problem and may manifest either as an increase in liver transaminase concentrations, which is relatively common (> 1%), or as a drug-induced hepatitis, which is rare (< 0.1%).10”Ĭavernous Neurotomy Causes Hypoxia and Fibrosis in Rat Corpus Cavernosum Because of these adverse effects, papaverine should be restricted to informed patients in whom other medications are ineffective. However, the efficacy of ICI papaverine is limited by local adverse effects, principally priapism (in 7%)8 and intracavernosal fibrosis, presenting as penile deformity or curvature (reported in one study in 50% and 95%, respectively, of long term users).9 Fibrosis is related to poor injection technique, frequent injections and long term use. After intracavernosal injection, the peak serum concentration is several times lower than after extracavernosal injection, suggesting that the corpus cavernosum is a separate pharmacokinetic compartment from which elimination of papaverine is much slower than from the systemic circulation.7Ī meta-analysis of the largest published studies on the use of papaverine reports that it is effective in 53% of men with ED, as measured by the ability to produce an erection of sufficient rigidity for sexual intercourse8 (E1). “Papaverine is a potent, non-specific smooth muscle relaxant which increases smooth muscle intracellular adenosine 3’,5’-monophosphate (cAMP) by its action as a non-selective cAMP phosphodiesterase inhibitor, causing vasodilatation of penile vascular and sinusoidal smooth muscle.6 Papaverine has a relatively short plasma half-life (1-2 hours) and is extensively metabolised in the liver.
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